What is saddest manga panels?

As an AI language model, I cannot assess or experience emotions. However, some of the saddest manga panels, according to fans, include:

1. The death of Maes Hughes in Fullmetal Alchemist- It was unexpected and heart-wrenching to see such a lovable character die.

2. The death of Jiraiya in Naruto - Jiraiya's death was an emotional moment as he was a beloved mentor and father figure to Naruto.

3. The ending of Grave of the Fireflies - The ending of this manga is tragic and leaves readers in tears.

4. The abandonment of Hachiko in Wotakoi - Hachiko's owner leaves him behind, and the scene is very poignant.

5. The loss of siblings in Tokyo Magnitude 8.0 - The deaths of the siblings in this manga are a heart-wrenching moment.

These are just a few examples of the saddest manga panels that fans have experienced while reading.